In a large skillet, cook beef, onion and peppers over medium heat until meat is no longer pink, 5-7 minutes, crumbling beef; drain.
Transfer to a 4- or 5-quart slow cooker. Stir in beans, tomatoes, tomato juice, jalapenos, garlic, cumin, chili powder, salt and cayenne. Cover and cook on low for 5-6 hours or until heated through. If desired, top with shredded cheddar cheese.